Promising preclinical findings show that the activation of 5-HT1 receptors, induced by the administration of 5-HT1A and/or 5-HT1B receptor agonists, suppressed LID in 6-OHDA-lesioned rat, as well as in MPTP-treated nonhuman primate models of PD, suggesting a possible clinical application.

This chapter will provide an overview of these preclinical findings concerning the role of serotonergic neurons and serotonergic receptors in the appearance of LID, with a brief review of relevant clinical studies.

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out that, by tacit little tricks in which even more than myself he carried out the care for my dignity, I had had to appeal to him to let me off straining to meet him on the ground of his true capacity.

An increasing body of experimental evidence suggests that serotonergic neurons play a major role in the production of levodopa-derived dopamine when dopaminergic neurons have degenerated, and that unregulated release of dopamine from serotonergic neurons is responsible for the appearance of levodopa-induced dyskinesia (LID) in animal models of Parkinson’s disease (PD).

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